Postdoc disponible en Francia

Post-doc position in Developmental Biology Development and evolution of median fin in chordates

A post-doc position is available in the group of Sébastien DARRAS. The group has been recently established at the marine station of Banyuls-sur-mer. 

We are interested in the molecular control of the ascidian Ciona intestinalis embryogenesis.  Our focus is on gene networks involved in patterning and differentiation of larval tail epidermis that gives rise to peripheral sensory neurons and median fin blades. We want to use the diversity of basal marine chordate species (tunicates and cephalochordates) available at the marine station to probe the evolution of median fin formation.

The post-doctoral research project aims at comparing at genomic and functional levels the  same developmental process in multiple species. Strong background in developmental and molecular biology, as well as curiosity are required. Experience with non-conventional model organisms will be appreciated.

Funding  by  the  French  Research  Agency  (ANR)  is  avalaible immediately, but applicants are expected to apply for their own financial support. 

Contact: Sébastien DARRAS (sebastien.darras@obs-banyuls.fr)

Laboratoire de Biologie Intégrative des Organismes Marins (BIOM)

UMR7232 CNRS-INSB-UPMC

Observatoire Océanologique de Banyuls

Avenue du Fontaulé

66650 Bany

Postdoc in Bordeaux-France

Postdoctoral positions in the Royou group

“Control and dynamics of cell division”

European Institute of Chemistry and Biology, 

CNRS, UMR5095, Bordeaux, France

Starting date: January 2013 or subject to negotiation

Duration: 3 years

Contact: a.royou@iecb.u-bordeaux.fr

Two post-doctoral positions funded by an ERC starting grant are available in Dr.  Anne Royouʼs group  (http://www.iecb.u-bordeaux.fr/index.php/fr/equipes/53-control-and-dynamics-of-cell-division)  at the European institute of Chemistry and Biology (IECB) (http://www.iecb.u-bordeaux.fr/).

The lab studies two axes relating to chromosome transmission during cell division using Drosophila as a model system. The first project explores the molecular mechanisms by which broken chromosomes are transmitted efficiently to daughter cells (Royou et a.,  Cell, 2010). The second project will provide insight into the mechanisms that coordinate  chromosome segregation with cell division (Montembault et al., JCB,  in press). The  candidate will work closely with other  team  members using complimentary approaches  including genetics, molecular biology, biochemistry and live imaging.

Candidates should hold a PhD and have a strong background in cell biology. We  are particularly interested in candidates who are familiar with the chromatin field. Expertise  in biophysics, microscopy, biochemistry or Drosophila genetics will also be welcomed.

The institute hosts young teams working in a multidisciplinary environment  at the  interface between Biology and Chemistry. The Royou group has access to cutting-edge  technology platforms available at IECB and the University of Bordeaux, providing state-ofthe-art mass spectrometry, structural biology and microscopy facilities.

Bordeaux is a dynamic city located in the South-West of France. It is 40 minutes from the nearest beach and surf spots, one hour from the Dordogne and 3 hours from the Pyrénées.

Candidates should send a  letter of motivation and a  CV including research  experience and a list of publications. Please also provide the name and contact details of  at least two referees.

Institut Européen de Chimie et Biologie

2, rue Robert Escarpit - 33607 Pessac, France

Tél. : +33(0)5 40 00 26 24 - Fax. : +33(0)5 40 00 22 15

www.iecb.u-bordeaux.fr

PhD position at the CBS

Investigating the toxic species in amyloid diseases: a structural perspective from solu-
                                                      tion scattering

Project description:
Protein fibrillation is associated with fatal amyloid diseases (e.g. Alzheimer’s and Parkinson’s diseases). Protein fibrils   may   damage   tissue   and   is   an   unwanted   reservoir   of   inactive   protein.   However,   the   neuro-degenerative effect observed for the mentioned diseases does not arise from the presence of fibrils, but rather from transiently formed non-native soluble oligomeric species. The structural events leading to these functionally central species pass through several un- and re-folding events that remain poorly understood. This is mainly because such nonnative structures are formed only in equilibrium with native and fibrillated protein forms and hence structural investigation is a significant challenge. In this PhD-project, we will further advance our previously developed Small-Angle X-ray Scattering data analysis approach (see Langkilde & Vestergaard (2012) Meth. Mol. Biol. for details) for a better understanding of the species involved in fibril formation, their mechanism of transformation, and the kinetics of the process. The candidate will develop an automated decomposition procedure, and apply it to several data-sets from different fibrillating proteins that are available in-house, supplemented with new experiments from the recently developed state-of-the-art synchrotron facilities. Protein systems related to Parkinson’s, Alzheimer’s and eukaryotic prion diseases will be investigated.

The candidate:
We are seeking a strong English-speaking candidate with a background in biostructural studies. Experience with software development and/or small angle scattering data analysis is considered highly advantageous. We welcome applications from all suitably qualified candidates.

The research environment:
The project is a collaboration between the BioSAXS group at the section of Biostructural Research; University of   Copenhagen,   Denmark   (see www.farma.ku.dk/br),   and   the   Centre   de   Biochimie   Structural   in   Montpellier, France (see www.cbs.cnrs.fr). The candidate will be employed by the Institute de la Santé et de la recherche Médicale  (INSERM), and will spend approximately half time in each of the two countries. The candidate will also obtain profound experience with high-quality SAXS data collection at the international large-scale infrastructures. The project is financed in concert by the Danish Council for Independent Research; Medical Sciences (Sapere Aude programme) and the INSERM.

HOW TO APPLY:
Applications - in English - must include:
     •    Cover Letter, detailing your motivation and background for applying for the PhD project
     •    CV
     •    Diploma and transcripts of records
     •    Other information for consideration, e.g. list of publications, peer reviewed and other
     •    Personal Recommendations if available

Please submit the application by email to Dr. Pau Bernadó at the following mail-address:
pau.bernado@cbs.cnrs.fr. Please mark the mail subject line with ’SAXS/fibrillation’
Deadline: October 15, 2012. Any applications received after the deadline will not be considered.
Expected project start: December 1st 2012.
Interested candidates are welcome to direct any questions to either Associate Professor Bente Vestergaard
(bente.vestergaard@sund.ku.dk; +45 35 336 403) or Associate Professor Pau Bernadó
(pau.bernado@cbs.cnrs.fr; +33 467417912

Postdoc position in Montpellier-France

Single Molecule Biophysics Group

Structure and Dynamics of Membrane Assemblies

Centre de Biochimie Structurale*, UMR5048 CNRS, U1054 INSERM

Post-Doctoral Position in Single Molecule Fluorescence Microscopy

A 2 years post-doctoral position is  available at The “Single Molecule 

Biophysics” group in Montpellier (France) to study molecular mechanisms involved 

in Hepatitis C Virus (HCV) entry. Our approach is multidisciplinary, bringing together 

virologists specialist in HCV and biophysicists using  state-of-the-art fluorescence 

single-molecule techniques. The project is funded by  a French Research Funding 

Agency (ANRS – Agence Nationale de Recherches sur le SIDA et les Hépatites 

Virales).

The project led by L. Cocquerel (Pasteur Institute, Lille) and P.E. Milhiet (CBS, 

Montpellier) aims to elucidate the dynamics and partitioning of transmembrane 

proteins implicated in HCV entry. These objectives will be achieved by the 

integration of  single-molecule tracking experiments (1,2) and super resolution 

microscopy (PALM and STORM) recently developed at the CBS (see the platform 

facility at  http://www.cbs.cnrs.fr/rubrique.php3?id_rubrique=582&EQUIP=Equipe2). 

These experiments will be combined with  protein silencing and generation of cell 

lines. The successful candidate will be mainly involved in the biophysics 

experiments and should have a PhD in biology or physics and experience in singlemolecule 

fluorescence experiments. Previous experience with cell biology will be 

considered favorably.

Please send full CV including research interests and the name of 2-3 referees 

by e-mail to: Pierre-Emmanuel Milhiet (pem@cbs.cnrs.fr, phone: 33 467417917), 

CBS, Montpellier, France.

*  CBS (http://www.cbs.cnrs.fr) is an Institute  dedicated to  research at the forefront of 

structural biology and biophysics as a means to reveal the fundamental physical mechanisms 

underlying biological activity and its regulation. It is recognize as an IBISA platform with facilities in 

nmr, crystallography, bioinformatics and biophysics. Montpellier is a stunning city on the French 

Riviera with a significant international community.

Publications

1) Espenel et al. (2008) J Cell Biol 182, 765-776.

2) Krementsov et al (2010) Traffic 11, 1401-1414.

Postdoc position in Paris

Postdoctoral position

High spatiotemporal Resolution microscopy to follow mRNAs ribonucleoparticles, from 

their biogenesis to their nuclear export in living Yeast cells.

A 2-years postdoctoral position funded by the Labex WHO AM I is available in the team of C. 

Dargemont at the Institut Jacques Monod (CNRS/Université Paris Diderot). This will be a 

collaborative project with teams of  P. Hersen (Matiere et Systemes complexes, CNRS/ 

Université Paris Diderot) and J. Salamero/C. Kervrann ( Serpico-PICT IBiSA; Institut CurieINRIA). 

Start date is between September and December 2012.

The interdisciplinary project proposes to combine the development of innovative superresolution 

methods, bioimage informatics approaches and genetic engineering in order to image 

the export-competent mRNP formation in yeast cells with time regimes compatible with kinetics 

to be observed and space resolution adapted to the limited size of the yeast nucleus.

The candidate will beneficiate from the combined expertise of Salamero’s, Kervrann’s, 

Dargemont’s and Hersen’s teams in bioimaging, bioimage informatics, mRNP biogenesis and 

nuclear export, and microfluidics applied to yeast biology.

The ideal candidate would have proven an in deep knowledge in photonic microscopy (optics, 

particle tracking, signal treatment) and eventually in biophysics but will be localized in a biology 

team.

Interested candidates should send a motivation letter, a CV, a list of publications and three 

reference letters to C. Dargemont (dargemont.catherine@ijm.univ-paris-diderot.fr).

References

-Dokudovskaya S, Waharte F, Schlessinger A, Pieper U, Devos DP, Cristea IM, Williams R, Salamero J, 

Chait BT, Sali A, Field MC, Rout MP, Dargemont C. (2011)  Mol. Cell Proteomics.

10(6):M110.006478.

-Vitaliano-Prunier, A*., Babour A.*, Hérissant, L.*, Apponi, L., Margaritis, T., Holstege, FCP, Corbett, 

AH, Gwizdek, C.* and Dargemont, C.* (2012) Mol Cell. 1: 132-139.

-Hayakawa, A., Babour, A., Sengmanivong, L. and Dargemont, C. (2012) J. Cell Biol. 1:19-27.

-Hersen P, McClean MN, Mahadevan L, and Ramanathan S. (2008) Signal Processing by the HOG MAP 

Kinase pathway, PNAS, 105, 7165-7170.

IGBMC Strasbourg - Graduate student and postdoctoral

Positions available for one postdoctoral researcher and one graduate student  in the field of Allergy and Inflammation

The research group led by Dr. Mei Li/Prof. Pierre Chambon at IGBMC seeks  candidates for one  postdoctoral researcher and one Graduate student and to join  the projects on "Pathogenesis of allergic diseases and cellular and molecular  mechanism of allergic inflammation".

The proposed projects use mouse as modeling system to study 1) cellular and  molecular mechanism in pathogenesis of allergic diseases including asthma and atopic dermatitis; 2) in vivo dissection of
immune cascades driven by epitheliumderived cytokines in allergic inflammation. Techniques include advanced genetic approaches, i.e. conditional knockout;  transgenic; reporter mice; inducible depletion  of specific immune cells, as well as cellular and molecular immunological tools.

The applicant:
-for postdocoral researcher: the applicant should  have PhD degree with good record  of publications. Research experience in the immunology, and cellular & molecular  biology is highly desirable. Experience in mouse work will be a plus.
-for graduate student: the applicant must hold a master degree.

How to apply:
Candidates should email a motivation letter, a CV and contact informaion of three  referees to:
Dr. Mei Li
Directeur de Rechercher au CNRS
Institut de Genetique et de Biologie Moleculaire et Cellulaire
1, rue Laurent Fries
67404 ILLKIRCH
Email: mei@igbmc.fr
>mei@igbmc.fr
Tel: +33 3 88 65 35 71 (Office) / +33 3 88 65 34 68 (Lab)

Location:
The laboratory is located in the Institut de Génétique et de Biologie Moléculaire et  Cellulaire
(<http://www.igbmc.fr/>http://www.igbmc.fr/), which is attached to CNRS, INSERM and Université  de Strasbourg, and provides a highly competitive and international research environment with broad range of research and state-of-the-art technological facilities.

Selected references:
Li, M., et al. 2000. Nature 407, 633-636.
Li, M., et al. 2005. Proc Natl Acad Sci U S A 102:14795-14800.
Li, M., et al. 2006. Proc Natl Acad Sci U S A 103:11736-11741.
Li, M.. et al. 2009 J. Invest. Dermatol. 129, 498-502.
Zhang, Z., et al. 2009. Proc Natl Acad Sci U S A 106:1536-1541.
Surjit, M, et al. 2011. Cell 145: 224-241
Leyva-Castillo, JM., et al. 2012 J. Invest.
Dermatol. doi: 10.1038/jid.2012.239.

Pos doc Position in Toulouse-France

Post-doctoral / Engineering position at the interface between cell biology and physics The Institute of Pharmacology and Structural Biology ( http://www.ipbs.fr/?-Career-Opportunities- ) is proud to announce an opening for a postdoctoral position in the research team of “Differentiation and activation of phagocytes” led by Dr. Isabelle Maridonneau-Parini. The central objective for this position is to develop new strategies in order to study the mechanosensing properties of podosomes in macrophages.
Podosomes are particular adhesion structures involved in proteolysis of the extracellular matrix and migration in 3-dimensional environments. Our group has recently developed an original and innovative approach involving atomic force microscopy and the use of elastic films allowing the dynamic measurement of  podosome stiffness (Labernadie et al. PNAS 2010) and of the force generated by these structures (Labernadie et al. manuscript in preparation).

The candidate will develop new tools to understand how mechanical forces are applied by podosomes along with the implementation of different approaches including micro- and nanocontact printing, fluorescence microscopy techniques (FRET, FRAP, photoablation, TIRF), and molecular and cell biology. The ideal candidate will be knowledgeable and have proven experience in biophysics and in cell biology.

The position is now open and the candidate can start as soon as September 1st 2012. The contract tenure is set ideally for three years, and its salary can range between 24000-28000€/year depending on the  candidate’s experience and in accordance with the French state public service salary scale.
Social security and health benefits are included. Interested applicants should submit a motivation letter, a curriculum vitae including a full list of publications and at least two references by September 15, 2012 to recrutement_ir2012@ipbs.fr. Submissions should include the mailing label “Postdoctoral position”.

Postdoc position in Paris

Postdoc position: nuclear pores and stem cell differentiation
Institut Jacques Monod, Paris, France

Job description
A postdoctoral position is available in the laboratory of Valérie Doye at the Institut Jacques Monod
(Paris, France) to analyze the contribution of the nuclear pore complexes (NPCs) to embryonic stem
cell differentiation. This position is funded for at least 2 years, starting at the end of 2012. A salary
in accordance with qualifications, including potential previous postdoctoral experience, will be
offered.
Previous studies have revealed that the Nup133 subunit of the NPC regulates stem/progenitor cell
differentiation by an as-yet unknown mechanism (Lupu et al., Dev Cell, 2008). In this project, the
candidate will combine various approaches (including in vitro cell differentiation using Nup133-
deficient ES cell lines, cell imaging, biochemistry and gene expression studies), to characterize the
molecular partners and cellular mechanisms underlying the role of Nup133 in stem cell
differentiation. In view of our previous studies (Zuccolo et al., EMBO J. 2007; Bolhy et al., J. Cell
Biol, 2011), the interplay between cell cycle progression and cell differentiation will particularly be
investigated.
This project will benefit from the techniques and tools already assembled through a joint
collaboration with the teams of E. Lacy (Sloan-Kettering Institute, New York) and J. Collignon
(IJM, Paris). The Institut Jacques Modod further provides state-of-the-art in-house facilities
(imaging, proteomics, genomics-transcriptomics), and a highly collaborative environment
(http://www.ijm.fr/en/ijm/research/research-groups/).

Qualification:
We are looking for a candidate with a history of excellent research productivity and independent
thinking. Candidates are expected to have a keen interest in cell and developmental biology.
Experience and skills in cell culture and basic molecular biology is required, along with openness to
explore novel approaches; additional experience in stem cell biology and cell imaging would be
appreciated but is not mandatory. Excellent spoken and written English is expected. Knowledge of
French is not required.

How to apply:
Candidates should submit a full CV, and at least 2 referee contact addresses or reference letters to
Valérie Doye: doye.valerie@ijm.univ-paris-diderot.fr.
The position will remain open until filled; however applications received by August 30th, 2012 will
be given priority.

Postdoctoral Position in France

"Study of Ca2+ signaling and its biological function(s) in the Fas/CD95 apoptotic and non-apoptotic pathways"

A 2 years ANR-funded postdoctoral position will be available in the “Death Receptor and Tumor Escape” (DRaTE) (http://www.irset.org/?page_id=366) laboratory (Dir. P. Legembre) of the INSERM U1085 IRSET institute (Dir B. Jégou) located in Rennes, France. Preferred start date is between October and November, 2012.

Our group is interested in the role of the Ca2+ second messenger in the control of the life and death outcomes of Fas/CD95 stimulation (Khadra et al. PNAS 2011, Tauzin et al. PLoS Biology, 2011). We are particularly interested in understanding the molecular mechanisms linking the CD95 death receptor to the  modification of the intracellular calcium homeostasis and how malignant cells use this signal to escape the host immune response and/or the chemotherapeutic regimens.
This is a unique opportunity for a young scientist to apply new and innovative global approaches to the study of the early signal transduction events of the Fas/CD95. The ideal candidate would have proven skills and an in deep theoretical knowledge in Ca2+ signaling (hands-on experience of Ca2+ imaging would be a great asset), molecular biology, biochemistry and cell culture techniques.
The selected candidate will receive the full support from the team to apply for permanent research positions at Inserm and CNRS French research institutes (Chargé de Recherche). The candidate must be enthusiastic with excellent communication skills in English and a good team spirit in order to join a young starting team located in an excellent research environment with all the start-of-the-art core facilities. He/she will beneficiate from a highly competitive scientific infrastructure, agreable living conditions and comprehensive support by permanent staff members.

Extremely motivated PhDs with outstanding CV are encouraged to apply.
Interested candidates should send a motivation letter, a CV, a list of publications and three reference letters to Dr. Aubin Penna (aubin.penna@univ-rennes1.fr) and Dr Patrick Legembre (patrick.legembre@inserm.fr).

Tél : +33 (0)2 23 23 48 07- Fax : +33 (0)2 23 23 47 94 - Email : patrick.legembre@inserm.fr
Inserm Unité 1085 - Université de Rennes 1 - Campus de Villejean - 35043 RENNES Cedex - France
Equipe/Team: “Death Receptors and Tumor Escape”

Post-doc Position for Bioinformatician

Epigenetics in alternative splicing

Alternative splicing is an important process to generate protein diversity that affects the vast majority of human genes. In the past few years, transcriptional regulators, chromatin conformation and non-coding RNAs have been shown to play a role in the regulation of alternative splicing1,2. Genome-wide studies showed a non-random distribution of histone and DNA modifications along genes, with special enrichment at exons. We recently found that histone marks directly regulate alternative splicing via recruitment of splicing factors by chromatin-adaptor complexes3. To continue these studies in my laboratory at the Institute of Human Genetics (IGH-CNRS), I am looking for a highly motivated and creative post-doctoral fellow with strong background in bioinformatics and expertise in analyzing complex ChIP-seq and RNA-seq data. IGH is a very stimulating international institute in an extremely charming and sunny city, Montpellier (South of France).
If interested, please send a CV, e-mail contact for three reference letters and a brief cover letter stating research interests and career goals to Reini F. Luco (lucoigh@gmail.com)

1 Luco RF, Allo M, Schor IE, Kornblihtt AR & Misteli T (2011) Cell 144: 16-26.
2 Luco RF and Misteli T (2011) Curr Opin Genet Dev 21(4): 366-72
3 Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith O & Misteli T (2010) Science 327:996-1000

Post-doc position

Dear all,

As most of you know, I am starting my own group at the Institute of Human Genetics
(IGH) in Montpellier, France.
I am currently looking for motivated graduate students to do a postdoc in the study of the
role of epigenetics and non-coding RNAs in the regulation of alternative splicing.
Please, could you help me spread the word and resend the attached advertisement to your
contacts and/or Institute mailing list?
Thanks a lot!!
Best,
Reini F.Luco
Junior Group Leader
Institut de Génétique Humaine - Montpellier
http://www.igh.cnrs.fr/EN/index.php

URGENT offres d'allocations de recherche à Montpellier

Requiero su atención debido a la posibidad URGENTE de candidatearse para bolsas de tesis del Labex EpiGenMed en Montpellier
http://www.epigenmed.fr/

Si bien el Labex está orientado a biología molecular, al menos uno de los temas propuestos a concurso comprende biología molecular, evolución y bioinformática., como se describe aquí

http://sympasrv.univ-montp2.fr/sympa/d_read/evolfrance/offres_emplois/BdMEpiGenMed_PhD_2012.pdf

El prcedimiento de candidatura es bien simple, pero la FECHA LIMITE ES EL 30 DE MARZO!
Vease el sitio del Labex para postularse. Contactarme por lo que concierna al tema mencionado
Cordialmente

Pierre Boursot




Bonjour à tous,

J'attire votre attention sur la possibilité URGENTE de candidater pour des bourses de thèse auprès du Labex EpiGenMed à Montpellier:

http://www.epigenmed.fr/

Bien que ce Labex soit orienté biologie moléculaire, au moins un des sujets proposés au concours est à cheval entre biologie moléculaire, évolution et bioinformatique, comme décrit ici:

http://sympasrv.univ-montp2.fr/sympa/d_read/evolfrance/offres_emplois/BdMEpiGenMed_PhD_2012.pdf

La procédure de candidature est très simple, mais la DATE LIMITE EST LE 30 MARS!

Voir le site du Labex pour candidater. Me contacter pour ce qui concerne le sujet mentionné.

Open post-doctoral position on HIV Immunopathogenesis in Paris

A post-doctoral position is available for two years to work on a translational research program focusing on immune correlates of disease progression in HIV infection. This program is funded by the ANRS in collaboration with Sidaction and INSERM.


The successful applicant will join the team "HIV pathogenesis and immunosenescence" led by Dr Victor Appay within the INSERM unit “Immunity and Infection” based at the Pitié-Salpétrière Hospital (in Paris).
http://www.umrs945.upmc.fr/en/team_5_hiv_pathogenesis_and_immunosenescence/hiv_pathogenesis_and_immunosenescence.html


A central research topic of our team is on the reasons behind the onset of immunodeficiency in HIV infection. In this context, we are interested in the concept of T lymphocyte exhaustion and its relevance in HIV pathogenesis. The successful applicant will study immune characteristics related to T-cell development and renewal, activation and inflammation in HIV infected individuals. She/he will study in particular the impact of vitamin D deficit in the establishment of elevated inflammation and/or the decline of immune competence in humans. The tasks will include: to develop new tools in cellular immunology, to generate ex vivo (patients) and in vitro (models) data, to analyse and communicate results, and to prepare manuscript for publication.


Requirements
The applicant must have a PhD with research experience in the fields of immunology/immunopathology/infectious diseases, be strongly motivated by the study of virus/host interactions, and have very good skills in communicating in English (oral and writing). Skills in cellular immunology and flow cytometry are required as well as a strong background in fundamental immunology. Experience in the field of infectious diseases and/or anti-viral immunity, self-motivation, ability to work independently and in collaboration, and experience in training students are additional assets. The successful applicant is expected to join the team within 4-5 months.


Applications including a curriculum vitae and a cover letter detailing your skills and motivations should be sent by email to: victor.appay@upmc.fr


Antonio José Alberdi, Ph.D.
Plate-Forme Génomique IUH-Hopital Saint-Louis
Institut Universitaire d'Hématologie
Hôpital Saint Louis
Paris 75010
France
Tel:                         +33 1 57 27 67 92            
e-mail: aalberdy@hotmail.com

Becas postdoc Pasteur (Francia)

The Institut Pasteur calls in 2012 to candidature for a postdoctoral grant in the Institut Pasteur International Network.

Objective
The Institut Pasteur International Division will finance one postdoctoral fellowship for a duration of two years to allow young researchers to realize their postdoctoral training in an institute of the Institut Pasteur International Network (RIIP) except metropolitan France. This fellowship aims at promoting and facilitating the realization of postdoctoral trainings of young French and foreign researchers in a laboratory of the RIIP.

Fellowship areas may include all themes developed in the laboratories of the RIIP: research on and surveillance of infectious diseases (physiopathology, immunology, microbiology, epidemiology, virology, parasitology).

The applicant must have a PhD.

Duration
This doctoral fellowship will be awarded for a duration of 2 years

Evaluation Criteria
A Selection committee will decide on the allocation of this postdoctoral fellowship according to the relevance of the project, the goals of the training and on the file of the candidates.

Before applying for the fellowship, candidates have to find a host laboratory in the International Network and a project.

Deadline for submissions:  May 31, 2012

Application procedure
- Traineeship Grant application form including:

• The description of the thesis project (2 pages maximum) including context, problematics, objectives and working program (activities, waiting results and schedule) with the amount and origin of the budget for the internship project.
• Applicant’s curriculum vitae (1 page)
• Presentation of previous research already done by the candidate and the results (2 pages maximum)
• Chronological list of scientific publications with copies of the most significant publications (preferably in RTF or PDF format). Mention only publication published in reviews with editorial reviewers, not mention the submitted publications or publications in progress.
• The applicant must indicate whether s/he has already received a fellowship from a French or international organisation in 2008 to 2010, and whether s/he has applied for any other fellowships in 2011 and, if so, at which institution(s). The applicant must provide general information on personal resources.
• Elements on the institute, the team and the supervisor (2 pages maximum) knowing that pre-required asked are the following ones:
  - the supervisor should have publications, an experience on the subject (or the methods) proposed for the postdoctoral traineeship, if possible, an HDR and give the commitment that he will be in post for all the postdoctoral traineeship duration;
  - the host team will received a "sufficient" size (a single researcher cannot constitute a team) and conditions of employment (scientific materials and environment) suited
• A letter from the Director of the host institute
• A letter from the head of the host laboratory pledging to give the necessary assistance to the applicant and specifying the name, qualifications and position of the researcher who will be supervising the applicant.

Required documents to be sent by email to boursesRIIP@pasteur.fr, Eliane Coëffier

Calendar

One call for proposals a year :
- Opening of the application period: February 7, 2012
- Deadline for application: May 31, 2012
- Notification of the selected candidate: mid of July 2012

Contact

Eliane Coëffier, PhD, Project Manager, International Division, Institut Pasteur
eliane.coeffier@pasteur.fr

RIIP-Info: Calls for application and proposal

1) Postdoctoral position in the Laboratory of /Trypanosoma/ Infectious Processes, Infection & Epidemiology Department

A postdoctoral fellowship is available to join the laboratory of /Trypanosoma/ Infectious Process at the Institut Pasteur in Paris, France, to work on a project funded by the Foundation for Medical Research (FRM) . To apply for this position, candidates must have a Ph.D. in biomedical Sciences and a scientific experience in the field of host-microorganism interaction (preferably with parasites) using /in vivo/ immunobiological approaches. Proven skills in cellular biology, particularly with /in vitro/ models of infection, are essential prerequisites for the further optimization and preclinical developmentof chemical compounds. Experience in biochemistry will be appreciated. Proficiency in French and English is required.

Interested candidates should submit their /Curriculum vitae/ and two reference letters to Paola Minoprio,pmm@pasteur.fr , dead-line April 15^th 2012.

FRM Project : «Optimization of proline racemase /TcPRAC/ inhibitors to treat Chagas' disease» ; 12 months postdoctoral fellowship, from September 1st 2012 - August 31th 2013.

2) Appel Blanc international avec la Chine (accord ANR-NSFC)

1. Sciences et technologies de l'information

2. Chimie verte ou chimie durable

http://www.agence-nationale-recherche.fr/programmes-de-recherche/appel-detail/programme-blanc-international-2-2012/

Date limite de soumission: 21 mars 2012 à 13 heures (heure de Paris)

3) Programme Xu Guangqi de l'ambassade de France en Chine

Ce programme soutient les coopérations dans leur phase de démarrage. La date limite de dépôt de candidature est fixée au 6 mars 2012. Site: http://www.egide.asso.fr

4) Partenariats Hubert Curien (PHC)

Programmes du ministère des affaires étrangères et européennes et du ministère de l'enseignement supérieur et de la recherche. Ces programmes ont pour objectif de développer les échanges S&T d’excellence entre les laboratoires de recherche des deux pays et s’articulant autour de thèses en cotutelle (à défaut en codirection) par les laboratoires français et du pays concerné par le PHC.

Toutes les informations relatives aux partenariats PHC sont sur http://www.egide.asso.fr/phc

-PHC Cai Yuanpei (Chine): date limite de candidature 20/03/2012.

-PHC PRAD (Maroc) : date limite de candidature le 30/03/2012

-PHC Van Gogh (Pays Bas) : date limite de candidature le 31/05/2012

5) Le Conseil européen de la recherche (European Research Council) ouvre ses appels d'offre pour les advanced grants 2012. Ces financements sont réservés aux chercheurs de très haut niveau ayant soutenu leur thèse depuis au moins 12 ans, qui souhaitent mener un projet de recherche exploratoire dans tous les domaines de la science et de la technologie.

Dates limites de candidature :

16 février 2012 (Sciences physiques et ingénierie)

14 mars 2012 (Sciences de la vie)

11 avril 2012 (Sciences humaines et sociales)

Ces financements sont ouverts aux chercheurs étrangers qui souhaiteraient venir travailler dans un laboratoire européen.

Toute information utile sur : http://www.eurosfaire.prd.fr/news/consulter.php?id=6356

6) Medicine for Malaria Venture (MMV)

Title: 10th Call for proposals for Malaria Drug Discovery, Development and Clinical Capacity Building Projects

MMV welcomes proposals in the context of drug discovery and development or capacity building. MMV has identified four basic categories of indications for antimalarial treatment:

(a) The hits‐to‐lead stage for new families of molecules specifically addressing the key priorities of the malaria eradication agenda: transmission blocking and prevention of P. vivax relapse.

(b) Proposals for chemical series with the potential for P. falciparum chemoprevention or blood stage efficacy as a result of long‐half lives are encouraged, though the project should already have initial confirmation of in vivo oral blood stage activity.   Early target validation falls outside of our mandate.

(c) In the clinical arena, new chemical entities.

(d) Applications regarding capacity building to develop new sites for first‐in‐patient testing of these new molecules, including both blood stage, transmission blocking and P. Vivax anti‐relapse capabilities.

The prime area of interest for MMV is for agents that fall into the first category of affordable treatment for non‐severe malaria in children, pregnant women and adults as we currently see this as the area of greatest medical need. MMV’s ultimate goal is to be able to develop treatments that are completed with a single dose (certainly no more than once a day dosing for three days) so as to ensure patient compliance, have a low cost of goods and which are likely to have activity against artemisinin‐resistant strains

Deadline: Deadline for receipt of letters of intent March 15th, 2012

Further information: more information about the call and application procedure is available at http://www.mmv.org/research-development/10th-call-proposals

Title: MMV Challenge Grant

Proposals are expected to be at the concept stage (i.e. no prior experimental work is required) and to last no more than a year. These Challenge Grants will be prioritized based on scientific merit and according to the MMV strategy, and can constitute:

a)  Screening: testing the MMV Malaria Box against malaria and other parasitological assays

b)  Medicinal Chemistry: perform hit‐to‐lead or optimization chemistry on any anti‐malarial series

c)  Translational and Clinical Development: new methods to study or validate the inhibition of P.vivax relapses or the interruption of transmission

Number of Awards: 10 grants of 50000 USD each

Deadline: Deadline for receipt of letters of intent March 15th, 2012

Further information: more information about the call and application procedure is available athttp://www.mmv.org/research-development/10th-call-proposals

Becas para realizar el doctorado Francia (CEA)

El Comisariado de Energía Atómica de Francia (CEA) ha abierto un programa de becas para realizar el doctorado en alguno de los 8 Institutos de investigación que la integran y que están ubicados en distintas ciudades de Francia. El llamado está orientado al área de Ciencias de la Vida. Se ofrecen alrededor de 30 becas.

La información está disponible en: www-dsv.cea.fr/phd-program

La inscripción vence el 11 de marzo de 2012. Durante el mes de mayo se darán los resultados y las becas comenzarán el 1 de octubre de 2012.

Beca Doctoral en Francia

El Comisariado de Energía Atómica de Francia (CEA) ha abierto un programa de becas para realizar el doctorado en alguno de los 8 Institutos de investigación que la integran y que están ubicados en distintas ciudades de Francia. El llamado está orientado al área de Ciencias de la Vida. Se ofrecen alrededor de 30 becas.
La información está disponible en: www-dsv.cea.fr/phd-program
La inscripción vence el 11 de marzo de 2012.
Durante el mes de mayo se darán los resultados y las becas comenzarán el 1 de octubre de 2012.

5 openings for permanent research positions at INRA,France

The Animal Genetics Division of INRA (Institut National de la Recherche  Agronomique), France, has 5 openings for permanent research positions at  the junior research scientist level (CR2). 

Deadline for application is February 28, 2012.

Complete profiles and information on the positions are at: http://www.inra.fr/drh/cr2012/listepardepartement-cr2.php?choix=GA&langue=EN

1) Methods of genomic selection and optimisation of genetic management for animal production systems based on crossbreeding CR2-2012-5-GA-1
You will develop research on methods for genomic selection in animal  production systems based on crossbreeding, with special emphasis on pig  breeding, and optimize the genetic management of the populations at the  same time. You will analyze the present selection schemes and evaluate  the impact of possible selection alternatives on genetic progress and on  the evolution of genetic variation within and between populations. 
Skills in Quantitative Genetics and Population Genetics, Statistics and  Modelling, and High Throughput Data Analysis. Good programming  knowledge. Basic knowledge or interest in Animal Science. Interest in 
operational use of research results. Effective teamwork abilities.
Before applying, contact:
Christèle ROBERT-GRANIE
Tel: 33 (0) 5 61 28 51 99      
E-mail: christele.robert-granie@toulouse.inra.fr 


2) Genomic selection of beef cattle breeds CR2-2012-5-GA-2
You will develop comparative genomics and integrative biology approaches  for the identification and the functional characterization of genes  involved in beef cattle muscular development and properties. One  priority will be the detailed study of genomic regions previously  identified in order to better understand the determinism of phenotypes  and to acquire new knowledge on genetic polymorphisms to be used in  selection. Skills in genomics and high throughput data analysis. Basic  knowledge or interest in animal Science. Interest in operational use of  research results. Some programming knowledge would be a plus. Good  communication and effective teamwork abilities are recommended.
Before applying, contact:
Véronique BLANQUET
Tel:             33 (0) 5 55 45 76 64      
E-mail: veronique.blanquet@unilim.fr 

3) Computational biology and bovine sequence data CR2-2012-11-GA-3 You will play a leading role in the analysis of next-generation DNA cattle sequences obtained in the framework of 1000 genome projects. You will put special emphasis on the near exhaustive determination of polymorphisms in individuals sequenced for genomic selection, and on fine mapping of segregating QTLs. Skills in Quantitative Genetics and Population Genetics, Bioinformatics and Statistics, and High Throughput Data Analysis. Good programming knowledge. Basic knowledge in Genomics. Effective teamwork abilities.
Before applying, contact:
Didier BOICHARD
Tel:             33 (0) 1 34 65 21 81      
E-mail: didier.boichard@jouy.inra.fr 

4) Characterization and modelling of the variability of farm animal genomes obtained with new sequencing technologies CR2-2012-11-GA-4 You will develop basic research on genome plasticity between individuals, with a focus on farm animal species, and on its modelling. You will also work on assembly and comparison of large scale sequences. You will take advantage of the synergy between animal and plant studies on these topics because your team works also with the plant   bioinformatics group in Toulouse. Skills in Bioinformatics, Applied  Mathematics and High Throughput Data Analysis. Good programming  knowledge. Basic knowledge in Genomics and Population Genetics. 
Effective teamwork abilities.
Before applying, contact: 
Thomas FARAUT
Tel:             33 (0) 5 61 28 54 57      
E-mail: thomas.faraut@toulouse.inra.fr 


5) Genomic selection of cattle and sustainability of livestock  production CR2-2012-5-GA-5 You will conduct research on multi-breed genomic selection of beef  breeds using several sources of molecular information, from markers up  to sequences. You will be in charge of developing methods taking  advantage of larger reference populations and transposing results  obtained on larger breeds, with a special emphasis on new traits to be  selected for in both dairy and beef breeds. Skills in Quantitative  Genetics and Population Genetics, Statistics and High Throughput Data  Analysis. Good programming knowledge. Basic knowledge or interest in  Animal Science. Interest in operational use of research results. 
Effective teamwork abilities.
Before applying, contact:
Didier BOICHARD
Tel:             33 (0) 1 34 65 21 81      
E-mail: didier.boichard@jouy.inra.fr 

Complete instructions to apply are at: 
http://www.inra.fr/drh/cr2012/informations.php?langue=EN
Please note that the applicants have to produce a scientific report  following formal guidelines, and that selection of the successful  candidates is in two stages. The  first stage-selection is based on the  reports sent in due time, and candidates selected on the basis of their  report are audited in the final, second stage.

EuroCancer StemCell recrute deux Post-Doc

Bonjour,

 

Le projet EuroCancer StemCell Training Network recrute actuellement deux Post-Doc. L’objectif de notre projet, financé par la Commission Européenne, est d’améliorer la formation offerte par les différents laboratoires et écoles doctorales dans le domaine de cellules souches cancéreuses.

 

En pièce jointe vous trouverez les fiches descriptive des postes offerts :

 

·         Experienced Reseacher (Post-Doc) à l’Institute Universitaire d’Hématologie, Université Paris-Diderot (Paris, France).

 

·         Experienced Researcher (Post-Doc) à Miltenyi Biotech (Cologne, Allemagne).

 

Je me permets d’ insister sur les critères d’éligibilité décrits dans les annonces, car ils sont imposés par la Commission Européenne et donc ne sont pas négociables.

 

Date limite pour la réception de candidatures (uniquement en Anglais): 15 janvier 2012.

 

Pour plus d’information : http://eurocsctraining.eu/

 

Postdoc fellow - Physical chemistry/bioengineering

Nanosciences Foundation and University of Grenoble, France
 Contacto correo-e:rrichter@cicbiomagune.es
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Physical Chemistry / Bioengineering / Glycobiology

"Biomimetic surfaces to interrogate carbohydrate-mediated cell trafficking"

In this multidisciplinary project, the postdoctoral fellow will use state-of-the-art surface biofunctionalization and in situ analysis methods to design advanced biomimetic surfaces. The biomimetic surfaces will be used in novel and quantitative biomolecular and cell biological assays, to study the role of glycosaminoglycans in cellular trafficking.

Cellular motion is guided by extracellular gradients of signaling proteins, so-called chemokines. A family of polysaccharides, known as glycosaminoglycans (GAGs), help organizing and presenting chemokines on the cell surface and in the extracellular matrix. How GAGs mediate cell migration is currently not well understood. There is reason to believe that the supramolecular presentation of GAGs (e.g. local density, orientation and mobility) is functionally important. The study of such effects poses a challenge, because the ability to control and characterize the presentation of GAGs, in vivo or in vitro, is to date very limited.

The goal of this research project is to develop multifunctional model surfaces that recapitulate selected aspects of the in vivo situation. State-of-the-art surface biofunctionalization and patterning methods (e.g. supported lipid bilayers, microfluidics) and a toolbox of surface-sensitive in situ analysis techniques (e.g. QCM-D, ellipsometry, RICM, AFM, ATR-FTIR, fluorescence methods) will be used to elaborate well-defined surfaces. The biomimetic surfaces will then be used for quantitative biomolecular and cell biological studies.

The team. The research project is part of an Excellence Chair, awarded by the Nanosciences Foundation in Grenoble to Ralf Richter, and will take place in a multidisciplinary team of four strong research groups in the Grenoble research area, led by Pierre Labbé (DCM, University of Grenoble), Hugues Lortat-Jacob (IBS), Catherine Picart (LMGP, Grenoble INP) and Roberto Calemczuk (SPrAM, CEA).

The environment. Grenoble is a pleasant city situated in the French Alps and is one of the most renowned scientific areas in France for biological and nanotechnological studies, providing a vibrant scientific environment.

Required qualifications and terms of employment. We are looking for an outstanding experimentalist with a solid background in physical chemistry, bioengineering, glycobiology or a closely related field. Solid experience with biosurface science is an advantage. The candidate should have keen interest in multidisciplinary work, disposition to collaborate actively with the project partners, and a strong drive to excel in a competitive international environment. The successful candidate will be hired by the Nanosciences Foundation, for the duration of two years, extendable by an additional year. The project can be started immediately. The working language is English.

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Información complementaria de la oferta:
Interested? Please send an informal application with a motivation letter on why you want to join the project, your CV and the contact information of two referees to Ralf Richter (rrichter@cicbiomagune.es).

Further information about the research activities of the Richter Group can be found under www.cicbiomagune.es. The activities of the Nanosciences Foundation are described under www.fondation-nanosciences.fr.