Description: Applications are now being accepted to be part of a multinational project funded by the Centres of Excellence in Neurodegeneration (COEN) in the laboratory of Dr. Claudio Cuello, at the Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada. The project entails the generation of new transgenic models of the Alzheimer’s pathology in rat, a species with numerous neurobiological and technical advantages. Using these transgenic rats, we will investigate factors mediating and influencing the earliest onset of synaptic changes and their implication in network dysfunction. The hypothesis is that dysregulation of the dynamics of synaptic plasticity and remodeling triggered by Aß and tau oligomer interactions underlies early impairment of hippocampus-dependent memory.
Requirements: Technically, this position involves handling of stereotaxic combined with pharmacological and viral approaches. The candidate should hold a Ph.D. and have a strong conceptual and experimental background in in-vivo research and molecular neuroscience. Experience with recombinant DNA techniques, in situ hybridization, neuroanatomy, immunohistochemistry, confocal microscopy, stereotaxy and rodent behavioral tests is desirable. The candidate should be proactive, independent, hardworking, productive, and enjoy working as part of a team. The most competitive candidates will be those with at least one first-author publication in the field and should be committed to eventually becoming self-funded beyond the terms of the current fellowship. Note that Quebec government regulations limit postdoctoral stages to the first five years following granting of a doctorate.
Please send your CV, a brief statement of current and future research interests, and three references to:
Ms. Maureen Driscoll,
Assistant to Dr. A. Claudio Cuello
Professor and Charles E. Frosst Merck Chair in Pharmacology
Faculty of Medicine
McGill University
3655 Sir-William-Osler Promenade, #1210
Montreal QC, Canada H3G 1Y6
E-mail: maureen.driscoll@mcgill.ca
Telephone: +1-514-398-3618
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