Indiana
University School of Medicine
Multiyear
post-doctoral position available to investigate the role of autophagy and a DNA
repair enzyme in drug sensitivity in the protozoan parasite Toxoplasma gondii. Related to the
malaria parasite, Toxoplasma causes serious disease in immuno-compromised
(AIDS) patients and during pregnancy. We have shown that disruption of a
mitochondrial MutS homolog results in multi-drug resistance and that this
protein is part of an inducible death pathway that includes cell cycle arrest
and autophagy. Potential projects include molecular and biochemical analyses of
mitochondrial function in the resistant mutant, characterization of signaling
event in the MutS dependent death pathway and investigation of autophagy as a
drug induced death pathway.
Position requires a
Ph.D., expertise in biochemistry, molecular and cellular biology, and excellent
communication skills (speaking and writing English). Experience in molecular
parasitology, DNA damage, autophagy, or mitochondrial function is a plus.
Submit cover letter, CV, and contact information for three references to Dr.
Gustavo Arrizabalaga (garrizab@iupui.edu).
Located in downtown
Indianapolis, Indiana University School of Medicine (IUSM) is the second
largest medical school in the US and boasts an outstanding intellectual atmosphere
and core facilities. IUSM was nationally ranked in the Top 30 Best Places to
Work for Postdocs. Our lab is part of a large intracellular parasitism group at
IU that fosters innovation and collaboration. IUSM is an equal opportunity
employer.
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