Instituto de Salud Carlos III
Contacto correo-e:mamblar@isciii.es
Searching for Posdoctoral
candidates
(Juan de la Cierva 2012 Call)
Group: Molecular Biology of Pneumococcus
Supervisor of the position: Dr. Mónica Amblar Esteban
Research interest of the group: Our group is interested in the role of
small non-coding RNAs as modulators of virulence in Streptococcus
pneumoniae.
Pneumococcus is the main etiological agent of community-acquired
pneumonia and a major cause of mortality and morbidity among children
and the elderly. Understanding how bacterial pathogens respond to
dynamic environments is a central aspect in microbial pathogenesis and
there are increasing evidences implicating small RNAs as vital
regulators of adaptation and virulence.
We have identified a big repertoire of small non-coding RNAs that are
expressed in S. pneumoniae using next-generation sequencing. Now, our
main goal is to elucidate how these small RNAs modulate gene expression
in pneumococcus to adapt its metabolic needs during infection. The work
will involve in vitro growing of bacterial cells under different stress
conditions, construction of knock out strains, genomic translational and
transcriptional fusions, analysis of gene expression through qRT-PCR
and Northern blot, analysis of virulence, etc.
Requirements:
1. PhD obtained on September 1, 2008 or later.
2. At least 2 first author papers in international journals.
3. Previous experience in bacterial manipulations and biochemistry and molecular biology techniques.
Interested candidates should send a cover letter and CV
(please include contact information for 2 referees)
before November 19, 2012 to:
Mónica Amblar Esteban: mamblar@isciii.es
Centro Nacional de Microbiología, Instituto de Salud Carlos III
Información complementaria de la oferta:
Interested candidates should send a cover letter and CV
(please include contact information for 2 referees)
before November 19, 2012 to:
Mónica Amblar Esteban: mamblar@isciii.es
Centro Nacional de Microbiología, Instituto de Salud Carlos III
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