Single Molecule Biophysics Group
Structure and Dynamics of Membrane Assemblies
Centre de Biochimie Structurale*, UMR5048 CNRS, U1054 INSERM
Post-Doctoral Position in Single Molecule Fluorescence Microscopy
A 2 years post-doctoral position is available at The “Single Molecule
Biophysics” group in Montpellier (France)
to study molecular mechanisms involved
in Hepatitis C Virus (HCV) entry. Our approach is multidisciplinary, bringing together
virologists specialist in HCV and biophysicists using state-of-the-art fluorescence
single-molecule techniques. The project is funded by a French Research Funding
Agency (ANRS – Agence Nationale de Recherches sur le SIDA et les Hépatites
Virales).
The project led by L. Cocquerel (Pasteur Institute, Lille) and P.E. Milhiet (CBS,
Montpellier) aims to elucidate the dynamics and partitioning of transmembrane
proteins implicated in HCV entry. These objectives will be achieved by the
integration of single-molecule tracking
experiments (1,2) and super resolution
microscopy (PALM and STORM) recently developed at the CBS (see the platform
These experiments will be combined with protein silencing and generation of cell
lines. The successful candidate will be mainly involved in the biophysics
experiments and should have a PhD in biology or physics and experience in singlemolecule
fluorescence experiments. Previous experience with cell biology will be
considered favorably.
Please send full CV including research interests and the name of 2-3 referees
by e-mail to: Pierre-Emmanuel Milhiet (pem@cbs.cnrs.fr, phone: 33 467417917),
CBS, Montpellier, France.
* CBS (http://www.cbs.cnrs.fr) is an Institute dedicated to research at the forefront of
structural biology and biophysics as a means to reveal the fundamental physical mechanisms
underlying biological activity and its regulation. It is recognize as an IBISA platform with facilities in
nmr, crystallography, bioinformatics and biophysics. Montpellier is a stunning city on the French
Riviera with a significant international
community.
Publications
1) Espenel et al. (2008) J Cell Biol 182, 765-776.
2) Krementsov et al (2010) Traffic 11, 1401-1414.
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