The NRW Research School BioStruct – Biological Structures in Molecular
Medicine and Biotechnology at Heinrich-Heine-University Duesseldorf in Germany, funded by the Ministry of Innovation, Science and Research of the German Federal State North Rhine-Westphalia (NRW), and the
school chairmen Prof. Dr. Lutz Schmitt and Prof. Dr. Dieter Willbold invite applications on PhD Scholarships starting in Spring 2012.
BioStruct offers innovative PhD education and research programs within a stimulating interdisciplinary environment combining the field of structural biology with molecular medicine and biotechnology. Highly motivated and excellent candidates holding an MSc or Diploma degree in the fields of Biochemistry, Biology, Chemistry, Physics and relatedfields can directly apply for a
PhD Scholarship for the project "Studying interactions of Membrane Proteins with ligands by DNP-enhanced Solid-State NMR Spectroscopy”
including a monthly stipend of 1345,- EUR and contributions towards travel and research expenses.
The ideal candidate should have a strong background in Physics and Biochemistry. Basic knowledge and experience in NMR or EPR spectroscopy is an advantage. A strong interest in Physics and structural biology and is a prerequisite. The applicant should be highly motivated, open for new approaches and techniques, and able to tackle demanding challenges. Workplace will be the exquisitely equipped Forschungszentrum Juelich in the group of Prof. Dr. Henrike Heise.
PhD Research Project Summary:
Transmembrane receptors and their interaction with ligand molecules still impose a major challenge upon structural biology: In the membrane-reconstituted state, such proteins are not accessible with liquid-state NMR spectroscopy, and crystallization protocols are far from standard. In the past decade, solid-state NMR spectroscopy has developed into a promising tool for structure elucidation or even determination of immobilized proteins which do not have to be crystalline nor soluble. One of the largest obstackles in solid-state NMR spectroscopy is still the low sensitivity. However, the inherently low sensitivity of nuclear magnetization can be overcome by exploiting the 660 times higher magnetic moment of unpaired electrons for signal enhancement via dynamic nuclear polarization (DNP). In 2012 our group will be equipped with one of the first DNP-spectrometers operating at a proton frequency of 600 MHz, in addition to existing state-of-the
art solid-state NMR spectrometers ranging from 600 MHz to 800 MHz. We are investigating several membrane receptors and their interactions with ligands. We also develop techniques tailored to specific questions and signal enhancement, and especially DNP will provide ample opportunities for methods developments.
BioStruct offers innovative PhD education and research programs within a stimulating interdisciplinary environment combining the field of structural biology with molecular medicine and biotechnology. Highly motivated and excellent candidates holding an MSc or Diploma degree in the fields of Biochemistry, Biology, Chemistry, Physics and relatedfields can directly apply for a
PhD Scholarship for the project "Studying interactions of Membrane Proteins with ligands by DNP-enhanced Solid-State NMR Spectroscopy”
including a monthly stipend of 1345,- EUR and contributions towards travel and research expenses.
The ideal candidate should have a strong background in Physics and Biochemistry. Basic knowledge and experience in NMR or EPR spectroscopy is an advantage. A strong interest in Physics and structural biology and is a prerequisite. The applicant should be highly motivated, open for new approaches and techniques, and able to tackle demanding challenges. Workplace will be the exquisitely equipped Forschungszentrum Juelich in the group of Prof. Dr. Henrike Heise.
PhD Research Project Summary:
Transmembrane receptors and their interaction with ligand molecules still impose a major challenge upon structural biology: In the membrane-reconstituted state, such proteins are not accessible with liquid-state NMR spectroscopy, and crystallization protocols are far from standard. In the past decade, solid-state NMR spectroscopy has developed into a promising tool for structure elucidation or even determination of immobilized proteins which do not have to be crystalline nor soluble. One of the largest obstackles in solid-state NMR spectroscopy is still the low sensitivity. However, the inherently low sensitivity of nuclear magnetization can be overcome by exploiting the 660 times higher magnetic moment of unpaired electrons for signal enhancement via dynamic nuclear polarization (DNP). In 2012 our group will be equipped with one of the first DNP-spectrometers operating at a proton frequency of 600 MHz, in addition to existing state-of-the
art solid-state NMR spectrometers ranging from 600 MHz to 800 MHz. We are investigating several membrane receptors and their interactions with ligands. We also develop techniques tailored to specific questions and signal enhancement, and especially DNP will provide ample opportunities for methods developments.
For further information on the NRW Research School BioStruct,
prerequisites and mandatory application forms please visit our website:
www.biostruct.de
Application Deadline for the current call: 20th February 2012
B. Haumann
application@biostruct.de
Heinrich Heine University, NRW Research School BioStruct
Duesseldorf, Germany
Application Deadline for the current call: 20th February 2012
B. Haumann
application@biostruct.de
Heinrich Heine University, NRW Research School BioStruct
Duesseldorf, Germany
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