PhD POSITION IN MOLECULAR VIROLOGY IN BERLIN AVAILABLE
in the lab of Prof. Christian Hagemeier working on VIRUS-HOST INTERACTIONS
Institute:
Charité Universitätsmedizin
Labor für Pädiatrische Molekularbiologie
Charité is a leading research institution in the field of Molecular
Medicine with an international, stimulating and interactive environment
and cutting edge infrastructure core facilities.
Research topic:
Human cytomegalovirus (HCMV) is a wide-spread pathogen that under normal
conditions establishes a latent, non-productive infection in its host.
In immunocompromised or immunonaive individuals, however, the lytic mode
of infection is favoured which can result in severe disease. The
control of viral immediate early (IE) gene expression is critical for
the decision between the latent and lytic mode of infection and
therefore represents an active focus of research. Our lab has discovered
that Cyclin A-associated kinase activity acts as a potent inhibitor of
IE gene expression and has further defined the Cyclin A substrate
mediating this effect (unpublished). The aim of the PhD project is to
characterize this virus-host interaction at the molecular level and to
study its contribution to HCMV latency in hematopoietic progenitor
cells. For information in greater detail please see: Zydek et al. (2011)
J Gen Virol 92, 2757; Zydek et al. (2010) PLoS Pathogens 6, e1001096;
Wiebusch et !
al. (2008) J Virol 82, 10188.
Requirements:
• Excellent grades during the qualifying degree (Diploma or M.Sc.) in biochemistry, molecular biology or molecular medicine
• Experience in standard molecular and cellular biology techniques
(i.e., cell culture, transfection, plasmid construction, PCR, protein
biochemistry).
• Good language skills in English
• You are ambitious, creative, goal-oriented, able to work well in a
team and to pay in depth attention to your experimental work.
Salary:
TV-Charité E13/ 50%
Starting date:
As soon as possible
Duration:
The position is available for three years.
Closing date for applications:
22.01.2012
Applications to:
Applications should be sent to christian.hagemeier@charite.de
The application should include a CV with description of previous
research experience and two references/letters of recommendation.
Information:
For further information please contact:
Dr. L. Wiebusch, e-mail: lueder.wiebusch@charite.de
Prof. C. Hagemeier, e-mail: christian.hagemeier@charite.de
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