PhD position in Biogenesis and morphology of mitochondria.

A PhD position is available in a young and dynamic group to study the biogenesis and morphology of mitochondria.
The project would utilize both tissue culture and yeast cells and will employ various genetic, biochemical, biophysical, and molecular cell biology methods.


Methoden:
Biophysical methods, Molecular cell biology, Protein chemistry, Yeast genetics, in vitro assays

Anfangsdatum: 1. Februar 2012

geschätzte Dauer: 36 Months

Bezahlung: TVL E13 (50-65%)

Veröffentlichungen:
1. Paschen, S.A., T. Waizenegger, T. Stan, M. Preuss, M. Cyrklaff, K. Hell, D. Rapaport, and W. Neupert. 2003. Evolutionary conservation of biogenesis of beta-barrel membrane proteins. Nature. 426:862-866.
2. Habib, S.J., T. Waizenegger, A. Niewienda, S.A. Paschen, W. Neupert, and D. Rapaport. 2007. The N-terminal domain of Tob55 has a receptor-like function in the biogenesis of mitochondrial beta-barrel proteins. J. Cell Biol. 176:77-88.
3. Walther, D.M., D. Papic, M.P. Bos, J. Tommassen, and D. Rapaport. 2009. Signals in bacterial beta-barrel proteins are functional in eukaryotic cells for targeting to and assembly in mitochondria. Proc. Natl. Acad. Sci. USA 106:2531-2536.
4. Papić, D., K. Krumpe, J. Dukanovic, K.S. Dimmer, and D. Rapaport. 2011. Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway. J. Cell Biol. 194:397-405.


Homepage: http://www.ifib.uni-tuebingen.de/forschung/rapaport.html