PhD - Synaptic signal integration and high resolution maps of synapses on dendrites of pyramidal neurons

The Remy lab studies the integration of synaptic signals on dendrites of pyramidal neurons. This position is funded over a period of 3 years and is part of a US-German collaboration between Stanford University, Northwestern University, HHMI Janelia Farm Research Campus and DZNE (CRCNS NIH/BMBF). We use patch-clamp recordings, multiphoton imaging, neurotransmitter uncaging and micrioiontophoresis to investigate the location dependent properties of inhibitory synapses on the dendritic tree and the dendritic interaction of excitation and inhibition. We will use our data to generate and improve existing computational models of pyramidal neuron function. The applicant will get the opportunity to obtain on site training in novel imaging techniques such as array tomography (Stephen Smith Lab, Stanford, CA) as well as computational modeling (Kath and Spruston Labs, Evanston, IL and Ashford, VA).

Methoden:
patch-clamp recordings, multiphoton imaging, neurotransmitter uncaging, neurotransmitter micrioiontophoresis, array tomography, computational modelling

Anfangsdatum: 1. Januar 2012

geschätzte Dauer: 3 years

Bezahlung: TvÖD

Veröffentlichungen:
Neuron. 2011 Aug 11;71(3):512-28.
Neuron. 2009 Mar 26;61(6):906-16.
PNAS. 2007 Oct 23;104(43):17192-7.

Homepage: http://www.dzne.de