A postdoctoral opportunity is currently available at the Medical School of the University of Rouen, France, to study the molecular mechanisms underlying RNA splicing defects associated with hereditary non-polyposis colorectal cancer (HNPCC or Lynch syndrome).
This syndrome is mainly due to alterations of the DNA Mismatch Repair (MMR) genes. We use a combination of molecular, biochemical and cellular approaches to identify germline mutations that alter the splicing pattern of these genes. We are especially interested in identifying and characterizing mutations that affect splicing regulatory elements.
The hosting laboratory, Inserm U614, is an INSERM (French Institute for Health and Biomedical Research) unit directed by Prof. Thierry Frébourg. The Inserm U614 is located at the Medical School of the University of Rouen, France, and it is affiliated to the Federate Institute for Multidisciplinary Research on Peptides (IFRMP 23). Research environment includes core facilities and access to clinical material from the University Hospital of Rouen and from the French Cancéropôle Nord-Ouest.
Applicants must hold a Ph.D. in cell biology, molecular biology, genetics or related areas.
Prior experience in techniques such as DNA and RNA isolation, cloning, PCR, cell culture, transfection, Western blotting, immunoprecipitation, and/or biochemical assays is preferred.
Skills in RNA biology would be especially valuable. Candidates are expected to be highly motivated and capable of independent initiative.
Interested candidates should send, as soon as possible, a curriculum vitae, a brief summary of research experience and career goals, and 2 reference letters (or the names and contact information of 2 references) to Dr. Alexandra Martins (alexandra.martins@univ-rouen.fr).
Postdoctoral position starting date: December 1st 2011
This syndrome is mainly due to alterations of the DNA Mismatch Repair (MMR) genes. We use a combination of molecular, biochemical and cellular approaches to identify germline mutations that alter the splicing pattern of these genes. We are especially interested in identifying and characterizing mutations that affect splicing regulatory elements.
The hosting laboratory, Inserm U614, is an INSERM (French Institute for Health and Biomedical Research) unit directed by Prof. Thierry Frébourg. The Inserm U614 is located at the Medical School of the University of Rouen, France, and it is affiliated to the Federate Institute for Multidisciplinary Research on Peptides (IFRMP 23). Research environment includes core facilities and access to clinical material from the University Hospital of Rouen and from the French Cancéropôle Nord-Ouest.
Applicants must hold a Ph.D. in cell biology, molecular biology, genetics or related areas.
Prior experience in techniques such as DNA and RNA isolation, cloning, PCR, cell culture, transfection, Western blotting, immunoprecipitation, and/or biochemical assays is preferred.
Skills in RNA biology would be especially valuable. Candidates are expected to be highly motivated and capable of independent initiative.
Interested candidates should send, as soon as possible, a curriculum vitae, a brief summary of research experience and career goals, and 2 reference letters (or the names and contact information of 2 references) to Dr. Alexandra Martins (alexandra.martins@univ-rouen.fr).
Postdoctoral position starting date: December 1st 2011
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